Caring Today for a Healthier Tomorrow and Forever Find A Doctor
Caring Today for a Healthier Tomorrow and Forever Find A Doctor
Jamia Nagar Okhla, New Delhi – 110025
Jamia Nagar Okhla, New Delhi – 110025
Myelofibrosis is a rare but serious blood cancer that affects the bone marrow's ability to produce blood cells, leading to complications such as severe anemia, enlarged spleen, fatigue, and bleeding issues. Without appropriate treatment, the condition can progress to acute leukemia or result in life-threatening complications.
India is increasingly becoming a global hub for advanced hematologic care, offering cutting-edge treatments for rare conditions like myelofibrosis—at a fraction of the cost charged in the West. From top-tier hospitals to globally trained specialists and affordable care, India is the preferred choice for thousands of patients worldwide.
Myelofibrosis is a type of chronic myeloproliferative neoplasm (MPN) in which the bone marrow is gradually replaced by fibrous scar tissue, impairing its ability to produce blood cells. It can occur as a primary disorder or as a secondary complication of other MPNs like polycythemia vera or essential thrombocythemia.
JAK2 (found in ~50–60% of cases)
CALR (~20–25%)
MPL (~5–10%)
These mutations cause abnormal cell signaling, which promotes uncontrolled growth of blood-forming cells.
Symptoms vary widely and depend on disease progression:
Severe fatigue and anemia
Enlarged spleen (splenomegaly)
Bone pain or discomfort
Night sweats, fever, and weight loss
Easy bruising or bleeding
Frequent infections
Diagnosis typically involves:
Blood tests – CBC, peripheral smear, LDH
Bone marrow biopsy – Confirm presence of fibrosis
Molecular/genetic testing – Detect JAK2, CALR, MPL mutations
Imaging – Ultrasound or MRI to assess spleen/liver size
Ruxolitinib (Jakavi) and Fedratinib are FDA-approved JAK inhibitors.
Benefits include spleen size reduction, symptom control, and improved quality of life.
Not curative but very effective in symptom management.
Lenalidomide, thalidomide, and androgens can help stimulate blood production and manage anemia.
Used to manage severe anemia and maintain hemoglobin levels.
Offers temporary relief, not a curative option.
Only curative option for eligible patients.
Most suitable for younger patients (<65 years) with high-risk disease.
Requires a matched donor (related or unrelated).
Success Rate in India: 60–70% long-term survival in matched-donor transplants.
Used to reduce spleen size or manage bone pain if medications fail.
Consider if the spleen is excessively enlarged and unresponsive to drugs or radiation.
Nutritional support, infection prevention, pain management, and emotional counseling are essential components of long-term care.
The success of treatment depends on the chosen therapy, patient’s age, stage of disease, and response to medications. Approximate success rates:
|
Treatment |
Success/Control Rate |
|
JAK Inhibitor Therapy |
60–80% (symptom control) |
|
Blood Transfusions |
90% (temporary relief) |
|
Bone Marrow Transplant |
60–70% (curative, long-term) |
|
Radiation Therapy |
50–70% (for spleen/bone pain control) |
|
Treatment Type |
Cost (INR) |
Cost (USD) |
|
JAK Inhibitor Therapy |
₹2,00,000 – ₹4,00,000 |
$2,500 – $5,000 |
|
Blood Transfusions (per) |
₹10,000 – ₹20,000 |
$125 – $250 |
|
Bone Marrow Transplant |
₹15,00,000 – ₹25,00,000 |
$18,000 – $30,000 |
|
Radiation Therapy |
₹1,50,000 – ₹3,00,000 |
$1,800 – $3,600 |
|
Splenectomy |
₹2,00,000 – ₹4,00,000 |
$2,500 – $5,000 |
Type of hospital (government vs. private, JCI/NABH-accredited)
Experience of the hematologist/oncologist
Complexity of treatment (especially bone marrow transplant)
Type and frequency of diagnostic tests
Duration of hospital stay
Supportive care needs (e.g., ICU, transfusions, medications)
Travel and accommodation (for international patients)
World-Class Hospitals: Fortis, Apollo, Tata Memorial, Max, and others are internationally accredited.
Top Hematology Specialists: Trained in the US/UK with global recognition.
Affordable Pricing: 60–80% lower costs compared to USA/UK.
Advanced Technology: PET-CT, molecular diagnostics, robotic surgery.
Fast Access to Treatment: Minimal waiting time for complex procedures.
Customized Treatment Plans: Every patient is unique. Medlivez works closely with leading specialists to offer individualized treatment plans tailored to your specific medical condition, preferences, and budget.
Access to India’s Top Hospitals and Doctors: Partnering with accredited hospitals (NABH/JCI) and renowned doctors, Medlivez connects you with world-class medical expertise across specialties like oncology, cardiology, orthopedics, fertility, organ transplant, and more.
Complete Visa, Travel & Accommodation Assistance: From medical visa invitations to airport pickups, hotel bookings, and local transportation—Medlivez handles all logistics so you can focus on recovery, not paperwork.
Transparent & Affordable Pricing: Medlivez guarantees honest, upfront pricing with no hidden charges. You receive a detailed cost estimate before starting your treatment, helping you plan with clarity and confidence.
Multilingual and Cultural Support: To make you feel at home, Medlivez provides interpreters and culturally sensitive support staff who speak your language and understand your needs—be it Arabic, French, Swahili, Russian, or others.
End-to-End Care Coordination: Medlivez ensures continuous support, from the moment you enquire until you are safely back home. This includes medical follow-ups, rehab support, post-op consultations, and even second opinions.
Trust and Compassion: With a track record of successfully coordinating treatment for patients from over 30 countries, Medlivez is known for its professional integrity, empathy, and round-the-clock responsiveness.
The success rate varies by treatment. Bone marrow transplants offer up to 70% long-term survival, while JAK inhibitors provide 60–80% symptom relief.
Eligibility depends on age, disease severity, overall health, and donor availability. A hematologist will assess and guide you.
Yes. India has a robust infrastructure for medical tourism with visa assistance, travel support, and international patient departments in major hospitals.
Absolutely. India houses globally accredited hospitals with dedicated bone marrow transplant units and skilled transplant teams.
Doctors can help find unrelated donors via international registries or suggest alternate therapies like JAK inhibitors and supportive care.
Currently, bone marrow transplant is the only potential cure. Other treatments help manage symptoms and improve life expectancy.
Regular follow-ups for blood counts, imaging, and monitoring medication response are crucial. Post-transplant care involves immunosuppression and infection control.
Some top centers include Apollo (Chennai, Delhi), Fortis (Mumbai, Gurgaon), Tata Memorial (Mumbai), and AIIMS (Delhi).
Some Indian and international health insurance plans cover part or all of the treatment. Confirm with your provider or facilitator.
Yes. Al Afiya Medi Tour coordinates with hospitals and registries to assist with all transplant logistics, including donor match and aftercare